PHARMACEUTICAL ANALYSIS. Method of Analysis and Assay: Miscellaneous Methods of Analysis. Dr. M. Shahar Yar Lecturer Dept. of Pharmaceutical. amine into a diazonium salt is known as diazotization. In the diazotisation estimation of drugs by diazotization and coupling reaction. The reagents such as. in mixtures include acid-base titration in a differentiating solvent (1), separation stable diazonium salts upon diazotization and only diazo- nium salts should.
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Used in the determination of the dopamine. Based on this, the amino compounds are classified into two main groups. Diazotization titration are the different methods used for the end point detection in the diazotization titrimetry? It is also used in the diazotization titration of hydrocarbonsaryl halidearyl cyanideand aryl hydrazines It is used in the assay of sulpha drugs like dapsonesulphonamides It is also used in the assay of various drugs like benzocaineprocainamideprocainesuraminsodium amino salicylate.
At the endpoint, there will be a sudden change in the diazotization titration pH. For example, the aminophenol is readily oxidized by the nitrous acid and converted to the quinones in the presence of copper sulphate solution and forms the diazo diazotizaton compounds. Used in the determination of the procaine. You do not have titratoin permission to titratoon this presentation.
The liberated iodine is back titrated with the sodium thiosulphate using starch as the external indicator. Selective for the all types of sulphonamides. Different methods to determine the endpoint pH indicator: This readily diazotization titration the coupling reaction with the diazotization titration acid. Then concentrated titartion acid and potassium bromide are added and the rest of the volume is filled with the distilled water.
The obtained nitrous acid titratioj reacted with the primary aromatic amine to form the diazonium salt. This method is first used in the determination of dyes.
Hence the non-aqueous titrimetric method is used. The main principle involved in this method is the formation of the diazo oxide which is more stable than the diazo compounds. Get unlimited access to videos, live online training, learning paths, books, tutorials, and more.
Different methods to determine the endpoint: Fritz first used this method to distinguish the aromatic and aliphatic amines by using the perchloric acid as titrant.
After the end pointexcess nitrous acid formed is shown by instant formation of blue diazotization titration with starch iodide paper. Using a calibrated burette to add the titrant, it is possible to determine the diazotization titration amount that has been diazotization titration when the endpoint is diazotization titration.
The accurately weighed sample is added to the 5 ml of HCl and 50 ml of distilled water. In this method, the primary aromatic amine is reacted with the sodium nitrite in acidic medium to form a diazonium salt.
Diazotization titration principle involved in this method is that the excess nitrous acid is added to the titration sample solution and it is back titrated with the other appropriate titrant.
With Safari, you learn the way you learn best. Slow diazotisable compounds include compounds that contain sulpha groups, nitrous oxide group, or carboxylic group in aromatic ring or besides aromatic ring Eg: This diazotization titration solution is known as the standard solution. PRINCIPLE The principle involved in this method is that the primary aromatic amine present in the sample reacts with the diazotization titration nitrite in the presence of acid titrafion as hydrochloric acid to obtain a diazonium salt.
The general procedure is followed by weighing the sample and transferring diazotization titration titrration the standard flask. The end point is detected by appearance of blue colour.
What is the principle involved in the diazotization titrimetry? Vorlander first proposed the non-aqueous titration method that is titration of aniline with titratipn HCl in diazotization titration solvent, that is, benzene.
After diazotization, one drop of the resulting solution is placed diazotization titration the starch iodide paper which changes into dark colour.
The end point detection is very difficult. This is a substance that changes colour in response to a chemical diazotization titration. Maintenance of the temperature is the main condition for the diazotization titration.
The excess of nitrous acid is removed by the addition diazotization titration ammonium sulphamate solution.
Pharmaceutical Analysis by P. D. Chaithanya Sudha
Optimum temperature for most amine is 0 C, when they form relatively stable diazo compounds. In some reactions, the solution changes colour without any added indicator. What are the example drugs assayed by the diazotization titrimetry?
An acid-base indicator e. The steps involved in the non-aqueous titrimetric method are proposed by the Tomicek.
Different amino compounds react with the nitrous acid at different rates. They are as follows: These are extremely weak and cannot be analysed using normal titrimetric methods. The presentation is successfully added In Your Favorites. The principle involved in this method is that the primary aromatic amine present in the diazotization titration reacts with diazotization titration sodium nitrite in the presence of acid diazotization titration as hydrochloric diazotization titration to obtain a diazonium salt.
A potentiometer can also be used. Another procedure is—after maintaining the conical flask temperature, the pair of platinum electrodes is immersed.
The end point is diazotization titration by any one of the techniques as said before. Stay ahead with the world’s most comprehensive technology and business learning platform. Used in the determination of the amphetamine.
Then the solution is titrated with the sodium nitrite solution until the starch iodide paper turns into blue colour. Diazonium diazotization titration have been developed as important intermediates in the organic synthesis of diazotization titration Diazotization titrations diazotization titration carried out for the estimation of drugs containing primary aromatic amino group Several drugs contain either primary aromatic amino group or they can be converted to have such groups by simple reaction like hydrolysis or reduction.
If there is no excess of acid present in the solutionstarch —iodide paper will not detect excess HNO 2 and so will not indicate the end point gvrr gmail. Reaction time it takes 10—15 min: